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Meet our Scientific Advisory Board

A highly experienced talented research team working together with a common purpose.

More than 15 years of NIH funded research

1.Wu, K., Yang, Y., Wang, C., Davoli, M.A., D'Amico, M., Li, A., Cveklova, K., Kozmik, Z., Lisanti, M.P., Russell, R.G., Cvekl, A., and Pestell, R.G., DACH1 inhibits transforming growth factor-beta signaling through binding Smad4. J Biol Chem. 2003 Dec 19; 278(51): p. 51673-84

2.Sunde, J.S., Donninger, H., Wu, K., Johnson, M.E., Pestell, R.G., Rose, G.S., Mok, S.C., Brady, J., Bonome, T., and Birrer, M.J., Expression profiling identifies altered expression of genes that contribute to the inhibition of transforming growth factor-beta signaling in ovarian cancer.Cancer Res. 2006 Sep 1; 66(17): p. 8404-12 

3.Wu, K., Li, A., Rao, M., Liu, M., Dailey, V., Yang, Y., Di Vizio, D., Wang, C., Lisanti, M.P., Sauter, G., Russell, R.G., Cvekl, A., and Pestell, R.G., DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growth.Mol Cell Biol. 2006 Oct; 26(19): p. 7116-29

4.Wu, K., Liu, M., Li, A., Donninger, H., Rao, M., Jiao, X., Lisanti, M.P., Cvekl, A., Birrer, M., and Pestell, R.G., Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth.Mol Biol Cell. 2007 Mar; 18(3): p. 755-67 

5.Sundaram, K., Mani, S.K., Kitatani, K., Wu, K., Pestell, R.G., and Reddy, S.V., DACH1 negatively regulates the human RANK ligand gene expression in stromal/preosteoblastcells.J Cell Biochem. 2008 Apr 15; 103(6): p. 1747-59. 

6.Wu, K., Katiyar, S., Li, A., Liu, M., Ju, X., Popov, V.M., Jiao, X., Lisanti, M.P., Casola, A., and Pestell, R.G., Dachshund inhibits oncogene-induced breast cancer cellular migration and invasion through suppression of interleukin-8. Proc Natl Acad Sci U S A. 2008 May 13; 105(19): p. 6924-9 

7.Wu, K., Katiyar, S., Witkiewicz, A., Li, A., McCue, P., Song, L.N., Tian, L., Jin, M., and Pestell, R.G., The cell fate determination factor dachshund inhibits androgen receptor signaling and prostate cancer cellular growth. Cancer Res. 2009 Apr 15; 69(8): p. 3347-55 

8.Popov, V.M., Zhou, J., Shirley, L.A., Quong, J., Yeow, W.S., Wright, J.A., Wu, K., Rui, H., Vadlamudi, R.K., Jiang, J., Kumar, R., Wang, C., and Pestell, R.G., The cell fate determination factor DACH1 is expressed in estrogen receptor-alpha-positive breast cancer and represses estrogen receptor-alpha signaling.Cancer Res. 2009 Jul 15; 69(14): p. 5752-60 

9.Nan, F., Lu, Q., Zhou, J., Cheng, L., Popov, V.M., Wei, S., Kong, B., Pestell, R.G., Lisanti, M.P., Jiang, J., and Wang, C., Altered expression of DACH1 and cyclin D1 in endometrial cancer.Cancer Biol Ther. 2009 Aug; 8(16): p. 1534-9. 

10.Popov, V.M., Wu, K., Zhou, J., Powell, M.J., Mardon, G., Wang, C., and Pestell, R.G., The Dachshund gene in development and hormone-responsive tumorigenesis.Trends Endocrinol Metab. 2010 Jan; 21(1): 

11.Attenuation of Forkhead signaling by the retinal determination factor DACH1.Zhou J, Wang C, Wang Z, Dampier W, Wu K, Casimiro MC, Chepelev I, Popov VM, Quong A, Tozeren A, Zhao K, LisantiMP, Pestell RG.Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6864-9. doi: 10.1073/pnas.1002746107. Epub 2010 Mar 29.PMID: 20351289 

12.   Cell fate determination factor Dachshund reprograms breast cancer stem cell function. Wu K, Jiao X, Li Z, Katiyar S, Casimiro MC, Yang W, Zhang Q, Willmarth NE, Chepelev I, Crosariol M, Wei Z, Hu J, Zhao K, Pestell RG.J Biol Chem. 2011 Jan 21;286(3):2132-42. doi: 10.1074/jbc.M110.148395. Epub 2010 Oct 11.PMID: 20937839 

13.Transcription elongation regulator 1 is a co-integrator of the cell fate determination factor Dachshund homolog 1. Zhou J, Liu Y, Zhang W, Popov VM, Wang M, Pattabiraman N, Suñé C, Cvekl A, Wu K, Jiang J, Wang C, Pestell RG.J Biol Ch Proc Natl Acad Sci U S A. 2008 May 13; 105(19): p. 6924-9 141. Epub 2010 Oct 18.PMID: 20956529 

14. The type 1 insulin-like growth factor receptor and resistance to DACH1. De Angelis T, Wu K, Pestell R, Baserga R.Cell Cycle. 2011 Jun 15;10(12):1956-9. doi: 10.4161/cc.10.12.15800. Epub 2011 Jun15.PMID: 21558809

15. Double homozygous missense mutations in DACH1 and BMP4 in a patient with bilateral cystic renal dysplasia. Schild R, Knüppel T, Konrad M, Bergmann C, Trautmann A, Kemper MJ, Wu K, Yaklichkin S, Wang J, Pestell R, Müller-Wiefel DE, Schaefer F, Weber S.Nephrol Dial Transplant. 2013 Jan;28(1):227-32. doi: 10.1093/ndt/gfs539. Epub 2012 Dec 21.PMID: 23262432   

16. Dachshund binds p53 to block the growth of lung adenocarcinoma cells. Chen K, Wu K, Cai S, Zhang W, Zhou J, Wang J, Ertel A, Li Z, Rui H, Quong A, Lisanti MP, Tozeren A, Tanes C, Addya S, Gormley M, Wang C, McMahon SB, Pestell RG.Cancer Res. 2013 Jun 1;73(11):3262-74. doi: 10.1158/0008-5472.CAN-12-3191. Epub 2013 Mar 14.PMID: 23492369  

17. EYA1 phosphatase function is essential to drive breast cancer cell proliferation through cyclin D1. W u K, Li Z, Cai S, Tian L, Chen K, Wang J, Hu J, Sun Y, Li X, Ertel A, Pestell RG.Cancer Res. 2013 Jul 15;73(14):4488-99. doi: 10.1158/0008-5472.CAN-12-4078. Epub 2013 May 1.PMID: 23636126  

 18. Acetylation of the cell-fate factor dachshund determines p53 binding and signaling modules in breast cancer. Chen K, Wu K, Gormley M, Ertel A, Wang J, Zhang W, Zhou J, Disante G, Li Z, Rui H, Quong AA, McMahon SB, Deng H, Lisanti MP, Wang C, Pestell RG.Oncotarget. 2013 Jun;4(6):923-35. doi: 10.18632/oncotarget.1094.PMID: 23798621  

19. Cell fate factor DACH1 represses YB-1-mediated oncogenic transcription and translation. Wu K, Chen K, Wang C, Jiao X, Wang L, Zhou J, Wang J, Li Z, Addya S, Sorensen PH, Lisanti MP, Quong A, Ertel A, Pestell RG.Cancer Res. 2014 Feb 1;74(3):829-39. doi: 10.1158/0008-5472.CAN-13-2466. Epub 2013 Dec 12.PMID: 24335958  

20. The endogenous cell-fate factor dachshund restrains prostate epithelial cell migration via repression of cytokine secretion via a cxcl signaling module. Chen K, Wu K, Jiao X, Wang L, Ju X, Wang M, Di Sante G, Xu S, Wang Q, Li K, Sun X, Xu C, Li Z, Casimiro MC, Ertel A, Addya S, McCue PA, Lisanti MP, Wang C, Davis RJ, Mardon G, Pestell RG.Cancer Res. 2015 May 15;75(10):1992-2004. doi: 10.1158/0008-5472.CAN-14-0611. Epub 2015 Mar 13.PMID: 25769723 

21. Endogenous Dach1 in cancer. Wu K, Yuan X, Pestell R.Oncoscience. 2015 Sep 23;2(10):803-4. doi: 10.18632/oncoscience.251. eCollection 2015.PMID: 26682253 

22. The retinal determination gene network: from developmental regulator to cancer therapeutic target. Kong D, Liu Y, Liu Q, Han N, Zhang C, Pestell RG, Wu K, Wu G.Oncotarget. 2016 Aug 2;7(31):50755-50765. doi: 10.18632/oncotarget.9394.PMID: 27203207  

23. Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance. Ozcan L, Ghorpade DS, Zheng Z, de Souza JC, Chen K, Bessler M, Bagloo M, Schrope B, Pestell R, Tabas I. Cell Rep. 2016 Jun 7;15(10):2214-2225. doi: 10.1016/j.celrep.2016.05.006. Epub 2016 May 26.PMID: 27239042  

24. DACH1 suppresses breast cancer as a negative regulator of CD44. Xu H, Yu S, Yuan X, Xiong J, Kuang D, Pestell RG, Wu K. Sci Rep. 2017 Jun 28;7(1):4361. doi: 10.1038/s41598-017-04709-2.PMID: 28659634 

25. DACH1 antagonizes CXCL8 to repress tumorigenesis of lung adenocarcinoma and improve prognosis. Liu Q, Li A, Yu S, Qin S, Han N, Pestell RG, Han X, Wu K.J Hematol Oncol. 2018 Apr 10;11(1):53. doi: 10.1186/s13045-018-0597-1.PMID: 29636079 

26. An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1. Zheng Z, Nayak L, Wang W, Yurdagul A Jr, Wang X, Cai B, Lapping S, Ozcan L, Ramakrishnan R, Pestell RG, Jain MK, Tabas I.Blood. 2019 Feb 14;133(7):743-753. doi: 10.1182/blood-2018-07-864843. Epub 2018 Dec 1.PMID: 30504459 

27. Dachshund Depletion Disrupts Mammary Gland Development and Diverts the Composition of the Mammary Gland Progenitor Pool. Jiao X, Li Z, Wang M, Katiyar S, Di Sante G, Farshchian M, South AP, Cocola C, Colombo D, Reinbold R, Zucchi I, Wu K, Tabas I, Spike BT, Pestell RG. Stem Cell Reports. 2019 Jan 8;12(1):135-151. doi: 10.1016/j.stemcr.2018.11.010. Epub 2018 Dec 13.PMID: 30554919  

28. Transcriptome-wide association analysis identifies DACH1 as a kidney disease risk gene that contributes to fibrosis. Doke T, Huang S, Qiu C, Liu H, Guan Y, Hu H, Ma Z, Wu J, Miao Z, Sheng X, Zhou J, Cao A, Li J, Kaufman L, Hung A, Brown CD, Pestell R, Susztak K .J Clin Invest. 2021 May 17;131(10):e141801. doi: 10.1172/JCI141801.PMID: 33998598

29 Li., X., Jiao,  X., Di Sante, G., Li., Z., DiRocco, A., Wang, M, Ertel, A, McCue, P., South, AP., Cordon-Cardo, C.,  Stokes, MP, Languino, L., Marra, M., Jones, SJ, Kossenko, A, Pestell, RG.. The  DACH1 gene is frequently deleted in prostate cancer, restrains prostatic  intraepithelial neoplasia, augments DNA damage repair and predicts therapy  responses. Oncogene 2023 Apr 24. doi: 10.1038/s41388-023-02668-9. Online ahead  of print.PMID: 37095257  

The Forkhead-like protein Dach1 governs sensitivity to WEE1 kinase and PARP inhibitors

Z Li, X Jiao, AG Robertson, AW Ashton, A Kossenkov, H Chen, LY Phoon, ...

Cancer Research 81 (13 Supplement), 2500-2500

 The DACH1 gene is frequently deleted in prostate cancer, restrains prostatic intraepithelial neoplasia, augments DNA damage repair and predicts therapy responsesLi, Z., Jiao, A. X., Robertson, G., Di Sante, G., Ashton, AW., Agnese DiRocco, A., Wang, M., Zhao, J., Addya, S., Wang, C., McCue, PA. South, AP., Cordon-Cardo, C., Liu, R., Patel,  K., Hamid, R., Parmar, J., DuHadaway, JB., Schultz, N., Kossenkov, A., Phoon, LY., Chen, H., Lan, L., Sun, Y., Iczkowski, KA, Rui,H. Pestell, RG , AACR Annual Meeting, 2023.